A Novel Near-Infrared Cyanine Dye for Bio Analytical Applications

Synthesis of a stable heptamethine cyanine dye 10 substituted with an isothiocyanato function for labeling with a near-infrared chromophore of biomolecules at amino groups is presented.Although the first near-infrared (NIR) absorbing dye was synthesized at the beginning of this century, the literature on the NIR dyes is quite limited (1).Recent years, however, have seen a renewed interest in the organic dye chemistry owing to a wide availability of inexpensive diode lasers which emit in the NIR region.NIR dyes have already found important applications as media for optical recording and thermal writing display, sensitizers for infrared