Human embryonic stem cell therapy for Parkinson's disease

Human embryonic stem cells (hESCs) may serve as the most enduring source of transplantable cells for Parkinson's disease patients. Accumulating experience in the transplantation of fetal midbrain tissue or cells into Parkinson's disease patients has set the stage for hESC therapy, but has also opened new controversies on the value and appropriate design of cell therapy. hESCs can be directed to differentiate into nigral dopaminergic neurons with high efficiency. The clinical use of hESCs will depend on their growth in controlled conditions, on whether safety can be proven, and on improving the survival of hESC-derived dopaminergic neurons in the host brain.