The cerebrospinal fluids of a number of sleeping sickness patients (T. rhodesiense infection) have been tested with Lange's colloidal gold reaction, and the total proteins present estimated. The estimation of the total protein present is the best guide to prognosis. It is also the best evidence in deciding when a patient is cured, and whether the case is one of relapse or reinfection. The colloidal gold reaction is influenced by treatment earlier than the percentage of protein present, and is, therefore, not so useful in prognosis. In general, the reaction is, “tabetic” in type, the intensity running parallel to the amount of protein present ; but when a general paralysis type of reaction is obtained, it is of grave prognostic significance.
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H. Fairbairn (1934) studied this question.
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