Introduction of a halogen atom at the middle carbon atom of cyclic 1,3-diketones is described. A convenient approach for constructing the spiro[4.4]nonane system of fredericamycin A has been demonstrated by halogen transfer during radical cyclization followed by reductive elimination of the halogen atom. The configuration of the bromo compound 6b was confirmed by X-ray crystal structure analysis.
No takes yet. Share an insight, caveat, or question.
RAO et al. (1993) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: