A single large dose of ethanol was given to fasted rats and to rats fed a fat‐free diet containing orotic acid. An increased plasma triglyceride concentration after ethanol feeding was consistently found in fasted male rats, while the results in fasted female rats varied between the experiments. The total rate of triglyceride secretion into the plasma in fasted rats was estimated as the Triton‐induced hypertriglyceridemia 6–7.5 hr after ethanol feeding. The effect of ethanol on the triglyceride secretion from extrahepatic sources was estimated in the same way in rats, with the hepatic triglyceride secretion blocked by orotic acid. Ethanol enhanced the Triton‐induced hypertriglyceridemia in both male and female fasted rats, but to a greater extent in male rats. Ethanol did not stimulate the extrahepatic triglyceride secretion during this period.
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Hernell et al. (1973) studied this question.
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