Key result
Highest serum calcium quartile linked to ~32% greater odds of elevated brachial-ankle pulse wave velocity.
Why the study?
Is elevated serum calcium level associated with elevated brachial-ankle pulse wave velocity in middle-aged and elderly Chinese subjects?
Cross-Sectional (n=9,615)
Is elevated serum calcium level associated with elevated brachial-ankle pulse wave velocity in middle-aged and elderly Chinese subjects?
Elevated serum calcium levels are independently associated with increased arterial stiffness, as measured by brachial-ankle pulse wave velocity, in middle-aged and elderly Chinese individuals.
Answers are grounded in this paper and cite their sources.
Higher serum calcium may relate to arterial stiffness; hypothesis-generating and should not yet change practice.
OBJECTIVE: To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. METHODS: The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was ⋝1752.5 cm/s (the upper quartile) either side. RESULTS: The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level (P<0.05). The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile (26.9%, 28.4%, and 33.2% vs 23.7%, P=0.0116, P=0.0004, and P<0.0001). Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile (OR=1.32, 95% CI: 1.08-1.60). CONCLUSION: The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
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Deng et al. (2014) conducted a cross-sectional in Arterial stiffness (n=9,615). Highest quartile of serum calcium level vs. Lowest quartile of serum calcium level was evaluated on Elevated brachial-ankle pulse wave velocity (≥1752.5 cm/s) (OR 1.32, 95% CI 1.08-1.60, p=<0.0001). The highest quartile of serum calcium was associated with a greater prevalence of elevated brachial-ankle pulse wave velocity compared to the lowest quartile (33.2% vs 23.7%; OR 1.32, 95% CI 1.08-1.60).
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