Trends in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis-Related Mortality in the United States, 1999 to 2017

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Letters21 January 2020Trends in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis-Related Mortality in the United States, 1999 to 2017Alexander W. Steinberg, MD, Michael E. Wechsler, MD, MMSc, and Evans R. Fernández Pérez, MD, MSAlexander W. Steinberg, MDSaint Joseph Hospital, Denver, Colorado (A.W.S.), Michael E. Wechsler, MD, MMScNational Jewish Health, Denver, Colorado (M.E.W., E.R.F.), and Evans R. Fernández Pérez, MD, MSNational Jewish Health, Denver, Colorado (M.E.W., E.R.F.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-1564 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The antineutrophil cytoplasmic autoantibody–associated vasculitides (AAV), including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis, are small vessel vasculitides that can affect nearly every organ system (1). Although rare, if left untreated these disorders are associated with substantial morbidity and mortality. Since the 1950s, immunosuppressive therapy has been the mainstay of treatment of active AAV (2). Data from a meta-analysis of 10 studies done between 1980 and 2005 suggest that trends in AAV-related mortality may have improved over time. Despite this, long-term outcomes continue to lag behind mortality rates of the general population (3). Furthermore, although population ...References1. Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65:1-11. [PMID: 23045170] doi:10.1002/art.37715 CrossrefMedlineGoogle Scholar2. Fauci AS, Haynes BF, Katz P, et al. Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med. 1983;98:76-85. [PMID: 6336643] LinkGoogle Scholar3. Tan JA, Dehghan N, Chen W, et al. Mortality in ANCA-associated vasculitis: ameta-analysis of observational studies. Ann Rheum Dis. 2017;76:1566-74. [PMID: 28468793] doi:10.1136/annrheumdis-2016-210942 CrossrefMedlineGoogle Scholar4. Wallace ZS, Lu N, Unizony S, et al. Improved survival in granulomatosis with polyangiitis: a general population-based study. Semin Arthritis Rheum. 2016;45:483-9. [PMID: 26323883] doi:10.1016/j.semarthrit.2015.07.009 CrossrefMedlineGoogle Scholar5. Centers for Disease Control and Prevention. About multiple cause of death, 1999-2017. Accessed at https://wonder.cdc.gov/mcd-icd10.html on 24 December 2018. Google Scholar Author, Article, and Disclosure InformationAffiliations: Saint Joseph Hospital, Denver, Colorado (A.W.S.)National Jewish Health, Denver, Colorado (M.E.W., E.R.F.)See also: Editorial comment (page 153)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1564.Reproducible Research Statement:Study protocol: Available from Dr. Steinberg (e-mail, [email protected]com) and Dr. Fernández Pérez (e-mail, [email protected]org). Statistical code: Not available. Data set: Available at https://wonder.cdc.gov.This article was published at Annals.org on 8 October 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDeadly Vasculitides and Reversed Racial/Ethnic Disparity? John R. Stone Metrics Cited byANCA-associated vasculitis in Caucasian and Hispanics of the Inland Empire of Southern CaliforniaVasculitisANCA-Associated Vasculitis in Latin AmericaTime trends in in-hospital mortality reduction in vasculitis vs. non-vasculitis hospitalisations vary by patient sex and ageThe impact of antineutrophil cytoplasmic antibody‐associated vasculitis on employment and work disability in an Australian populationTrend and Geographic Disparities in the Mortality Rates of Primary Systemic Vasculitis in the United States from 1999 to 2019: A Population-Based StudyANCA-associated vasculitisDeadly Vasculitides and Reversed Racial/Ethnic Disparity?John R. Stone, MD, PhD 21 January 2020Volume 172, Issue 2Page: 160-163KeywordsAtrial premature contractionDeath ratesDisclosureEpidemiologyInternational Classification of DiseasesLung and intrathoracic tumorsMortalityRacial and ethnic issuesRegression analysisVasculitis ePublished: 8 October 2019 Issue Published: 21 January 2020 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...