Key result
Neuroleptic dose and serum levels show no correlation with LNNB performance in chronic schizophrenics.
Why the study?
Does neuroleptic dose and serum level correlate with neuropsychological performance in chronic schizophrenia?
Cross-Sectional (n=30)
Does neuroleptic dose and serum level correlate with neuropsychological performance in chronic schizophrenia?
Neuroleptic serum levels do not appear to significantly correlate with neuropsychological performance on the LNNB in patients with chronic schizophrenia.
Should not guide neuroleptic dosing for cognitive effects; leaves open longitudinal studies in chronic schizophrenia.
The relationship of neuroleptic dose and blood serum levels to performance on the Luria Nebraska Neuropsychological Battery in chronic schizophrenics was assessed. Thirty chronic schizophrenics were individually administered the LNNB and a small sample of blood was obtained. No significant correlation between neuroleptic serum levels and test performance in these subjects was found although different conversion formulas related differentially to the blood serum levels.
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Puente et al. (1996) conducted a cross-sectional in Chronic Schizophrenia (n=30). Neuroleptic dose and blood serum levels was evaluated on Performance on the Luria Nebraska Neuropsychological Battery (LNNB). Neuroleptic dose and blood serum levels showed no significant correlation with neuropsychological performance on the LNNB in chronic schizophrenics.