Key result
Higher serum dialyzable CK inhibitor levels correlate with greater myositis severity.
Observational
The presence of a dialyzable CK inhibitor in the sera of patients with muscle disease may lead to underestimation of CK activity and correlates with disease severity.
May underestimate CK activity in myositis; hypothesis-generating for inhibitor as severity marker.
Sera from patients with muscle disease contain an inhibitor of creatine kinase (CK) which may lead to underestimation of CK activity. The inhibitor was dialyzable, but was not related to previously described low molecular weight inhibitors of CK. In a small group of patients with myositis, the amount of inhibitor present in serum was correlated with the severity of the illness. Our findings suggest that the CK inhibitor may be released into serum from injured muscle.
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Kagen et al. (1987) conducted an observational in Muscle disease (myositis). Creatine kinase (CK) inhibitor in sera was evaluated on Correlation of inhibitor amount with illness severity. The amount of a dialyzable creatine kinase inhibitor in the sera of patients with myositis correlated with the severity of the illness.
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