What question did this study set out to answer?

To identify chromosomal loci harboring genes that regulate baseline plasma levels of sex hormone-binding globulin and steroid hormones in Black and White families.

August 1, 2002The Journal of Clinical Endocrinology & MetabolismOpen Access

A Genome-Wide Linkage Scan for Steroids and SHBG Levels in Black and White Families: The HERITAGE Family Study

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Authors

OUO. UkkolaPennington Biomedical Research Center

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Implication

Family linkage study identifies chromosomal regions linked to sex hormone-binding globulin and steroid levels in Black and White families, suggesting polygenic control across ancestries.

Key Points

To identify chromosomal loci harboring genes that regulate baseline plasma levels of sex hormone-binding globulin and steroid hormones in Black and White families.
Genotyped 509 autosomal markers across 22 autosomes in participants from the HERITAGE Family Study, evaluating up to 357 White sibling pairs and 103 Black sibling pairs.
Measured baseline plasma concentrations for sex hormone-binding globulin (SHBG) and 10 steroid hormones, conducting singlepoint and multipoint linkage analyses.
Significant linkages for SHBG were detected in Black families on 1q44, 5p13.3, 10q24.1, and 12q12 (LOD > 3.6, P < 2.2 × 10⁻⁵ in singlepoint and multipoint analyses), with promising linkage on 1q44 in White families (1.75 < LOD < 3.6, P < 0.0023).
Promising linkage signals emerged across ancestries for C21 steroids on 1q43, 2p25.1, and 18q21.32 in Whites and 3q25.33 in Blacks (P < 0.0023), alongside distinct linkages for C19 and C18 steroids including 22q12.3 for testosterone in Whites (multipoint P = 0.0024) and 8q22.1 for dihydrotestosterone in Blacks.

Cite This Study

O. Ukkola (2002) studied this question.

synapsesocial.com/papers/6aa59af822b054842339619f https://doi.org/10.1210/jc.87.8.3708

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Implication

Family linkage study identifies chromosomal regions linked to sex hormone-binding globulin and steroid levels in Black and White families, suggesting polygenic control across ancestries.

A Genome-Wide Linkage Scan for Steroids and SHBG Levels in Black and White Families: The HERITAGE Family Study

Discussion

Member takes

Implication

Key Points

Cite This Study

A Genome-Wide Linkage Scan for Steroids and SHBG Levels in Black and White Families: The HERITAGE Family Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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