Key result
Fatal myofibroblast sarcoma with unexplained pleural maculopathy highlights the need for deep tissue biopsy.
Case Report (n=1)
In patients with myofibroblast sarcoma and pleural macula without other causative factors, a deep tissue biopsy of the pleura should be actively performed to confirm the diagnosis.
Supports biopsy consideration in sarcoma with unexplained pleural maculopathy; leaves open survival impact in larger cohorts.
Myofibroblastic sarcoma (MS) is a malignant tumor of soft tissue or bone that can occur in children or adults, with a high rate of recurrence and metastasis. We report a case of low-grade malignant MS of the left shoulder, diagnosed based on pathological examination and immunohistochemical staining. However, the patient had unexplained pleural maculopathy. The patient passed away 6 months after the diagnosis of myofibroblast sarcoma due to multiple metastases throughout the sarcoma. Combined with the patient's history, ancillary findings, and after MDT discussion, the patient was ultimately considered to have a high probability of myofibroblast sarcoma combined with pleural maculopathy. In conclusion, when a patient is diagnosed with myofibroblast sarcoma in combination with pleural macula, in the absence of other causative factors, a deep tissue biopsy of the pleura should be actively performed to confirm the diagnosis.
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Tu et al. (2023) conducted a case report in Myofibroblast Sarcoma Combined with Pleural Maculopathy (n=1). A 37-year-old man with myofibroblast sarcoma and unexplained pleural maculopathy died from multiple metastases 6 months after diagnosis, highlighting the need for deep tissue biopsy of the pleura.
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