Glycerol Phosphate Dehydrogenase in Rat and Mouse Liver Peroxisomes*

Isolated peroxisomes from rat liver and kidney' and mouse liver' contain 5 to 10% of the total cellular NAD-linked glycerol-3-phosphate dehydrogenase EC (1.1.1.8).although most of this activity is located in the cytosol.Since multiple forms of this enzyme have been reported to exist in animal different subcellular locations might be expected.Therefore the properties of the dehydrogenase as isolated from the peroxisomal fraction of rat and mouse liver have been compared with the cytosolic form.