Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non-cross-linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer-coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro.
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Liong et al. (2010) studied this question.