Key result
Metabolic risk factors linked to higher CVD risk, with diabetes showing the strongest association.
Why the study?
The complex interrelationships and relative contributions of metabolic syndrome components to CVD risk in the Saudi population remained poorly understood.
Population
2494 Saudi adults (1247 with MetS and 1247 matched controls)
Comparison
Adults with MetS vs matched controls
Design
Cross-sectional study
Authors
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Supports metabolic screening emphasis in Saudi CVD prevention; hypothesis-generating and requires prospective validation before practice change.
Cross-Sectional (n=2,494)
Yes
Effect estimate: β = 0.53 for diabetes
Diabetes, hypertension, dyslipidemia, and obesity significantly contribute to CVD risk in the Saudi population, mediated by inflammation, insulin resistance, and endothelial dysfunction.
Alkharasani et al. (2025) conducted a cross-sectional in Metabolic syndrome and cardiovascular disease (n=2,494). Metabolic syndrome and its components (diabetes, hypertension, obesity, dyslipidaemia) vs. Matched controls without metabolic syndrome was evaluated on Cardiovascular disease risk (β = 0.53 for diabetes). Metabolic risk factors significantly contributed to cardiovascular disease risk, with diabetes showing the strongest effect (β = 0.53), followed by hypertension (β = 0.47).
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