Key result
An intrasubunit TM1-TM2 hydrogen bond controls gating and determines pH sensitivity in Kir potassium channels.
Population
Inwardly rectifying potassium (Kir) channels
Design
Preclinical
Authors
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May guide Kir channel drug design in pH disorders; leaves open translation from animal models to human physiology.
Identifies an intrasubunit hydrogen bond between TM1 and TM2 as a conserved gating motif controlling Kir channel physiology.
Rapedius et al. (2007) studied Kir channel physiology. Intrasubunit hydrogen bond between TM1 and TM2 was evaluated on Gating motion of TM helices and channel pH sensitivity. An intrasubunit hydrogen bond between TM1 and TM2 at the helix-bundle crossing controls the gating motion of transmembrane helices and determines pH sensitivity in Kir potassium channels.