[reaction: see text] Pd(PPh3)4-catalyzed isomerization of MCPs 1 in acetic acid proceeds smoothly at 80 degrees C in toluene to give the corresponding 1-substituted or 1,1-disubstituted dienes 2 in good to excellent yields under mild conditions. The plausible mechanism has been disclosed on the basis of a deuterium-labeling experiment.
No takes yet. Share an insight, caveat, or question.
Shi et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: