Key result
Combined PEC1/SAB block cuts 24-hour postoperative morphine use ~49% versus no block and outperforms PVB.
Why the study?
Does Dual Pectoral Nerve and Serratus Anterior Blocks improve Postoperative Analgesia in patients undergoing breast surgery?
RCT (n=90)
Sealed envelopes
No
Does Dual Pectoral Nerve and Serratus Anterior Blocks improve Postoperative Analgesia in patients undergoing breast surgery?
Effect estimate: 49.2% reduction vs control, 14.8% reduction vs PVB
Absolute Event Rate: 4.05% vs 7.95%
p-value: p=<0.0001 vs control, 0.041 vs PVB
May reduce opioid needs after breast surgery; hypothesis-generating and needs randomized confirmation before practice change.
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Amir Abouzkry (2021) conducted an RCT in Breast cancer requiring modified radical mastectomy (n=90). Combined pectoral and serratus anterior block (PEC1/SAB) vs. Paravertebral block (PVB) or no block (Control) was evaluated on 24-hour postoperative mean amount of morphine consumption (49.2% reduction vs control, 14.8% reduction vs PVB, p=<0.0001 vs control, 0.041 vs PVB). Combined pectoral and serratus anterior (PEC1/SAB) block significantly reduced 24-hour postoperative morphine consumption by 49.2% compared to no block and by 14.8% compared to paravertebral block.
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