Tailored handcuffs: α-Azide-ω-alkyne oligomers are obtained in high yields from copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC), iterative chain growth, and protection–deprotection strategies. Intramolecular CuAAC under pseudo-high-dilution conditions then yields macrocycles with n=1–8 triazole units in the cyclic backbone (picture shows n=2; C gray, O red, N blue, H white).
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Binauld et al. (2009) studied this question.
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