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Acetaminophen toxicity remains a leading cause of acute liver failure in the United States and world-wide. Fomepizole is a cytochrome P450 inhibitor that may inhibit production of toxic metabolites of acetaminophen. However there are limited clinical data of its use for this purpose in the literature. Here we present a case series of six patients treated with fomepizole for acute acetaminophen toxicity who sustained no substantial liver injury.
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Rampon et al. (2019) studied this question.
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