Case report reveals severe corticospinal and cerebellar pathology in early-onset Alzheimer's disease, highlighting rare motor presentations.
An unusual case of Alzheimer's disease (AD) is reported. The patient was a 33-year-old Japanese housewife who had progressive dementia, severe spasticity, and mild ataxia for six years. Postmortem examination revealed severe changes of AD and degeneration of the corticospinal tracts, as well as neuritic plaques and plaquelike degeneration in the cerebellum. This appears to be the twelfth reported case of AD with spasticity and ataxia.
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Aikawa et al. (1985) studied this question.
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