Zinc-Induced Copper Deficiency: Megamineral Sideroblastic Anemia

Brief Reports1 September 1985Zinc-Induced Copper Deficiency: Megamineral Sideroblastic AnemiaWILLIAM P. PATTERSON, M.D., MICHAEL WINKELMANN, B.A., MICHAEL C. PERRY, M.D.WILLIAM P. PATTERSON, M.D., MICHAEL WINKELMANN, B.A., MICHAEL C. PERRY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-385 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe essential trace element zinc is necessary for growth and is involved in several physiologic functions. Zinc deficiency has been implicated in poor wound healing, immunologic impairment, hypogonadism, and growth failure (1). Because of these observations, food fadists and uninformed health-care providers have encouraged high daily doses of oral zinc to prevent or treat various illnesses. We report the case of a patient taking more than 30 times the usual daily mixed diet content of 10 to 15 mg of zinc for over 2 years as a treatment for "prostate trouble." Large quantities of ingested zinc may interfere with copper...References1. CHANDRA R. Excessive intake of zinc impairs immune responses. JAMA. 1984;252:1443-6. CrossrefMedlineGoogle Scholar2. BREWERHILLPRASADCOSSACKRABBANI GGAZP. Oral zinc therapy for Wilson's disease. Ann Intern Med. 1983;99:314-19. LinkGoogle Scholar3. BOTTOMLEY S. Sideroblastic anemia. Clin Haematol. 1982;11:389-409. CrossrefMedlineGoogle Scholar4. DUNLAPJAMESHUME WGD. Anemia and neutropenia caused by copper deficiency. Ann Intern Med. 1974;80:470-6. LinkGoogle Scholar5. ZIDARSHADDUCKZEIGLERWINKELSTEIN BRZA. Observation on the anemia and neutropenia of human copper deficiency. Am J Hematol. 1977;3:177-85. CrossrefMedlineGoogle Scholar6. WILLIAMS D. Copper deficiency in humans. Semin Hematol. 1983;20:118-28. MedlineGoogle Scholar7. MASON K. A conspectus of research on copper metabolism and requirements of man. J Nutr. 1979;109:1979-2066. CrossrefMedlineGoogle Scholar8. MENARDMCCORMICKCOUSINS MCR. Regulation of intestinal metallothionein biosynthesis in rats by dietary zinc. J Nutr. 1981;111:1353-61. CrossrefMedlineGoogle Scholar9. RICHARDSCOUSINS MR. Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis. Biochem Biophys Res Commun. 1975;64:1215-73. CrossrefMedlineGoogle Scholar10. DAYPANEMANGALOREBRADY FMF. In vivo and ex vivo effects of copper on rat liver metallothionein. Proc Soc Exp Bio Med. 1981;168:306-10. CrossrefMedlineGoogle Scholar11. WILLIAMSLOUKOPOULOSLEECARTWRIGHT DDGG. Role of copper in iron metabolism. Blood. 1976;48:77-85. CrossrefMedlineGoogle Scholar12. PRASADBREWERSCHOOMAKERRABBANI AGEP. Hypocupremia induced by zinc therapy in adults. JAMA. 1978;240:2166-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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