Key result
High-dose vitamin D3 supplementation followed by withdrawal induces human-like coronary atherosclerosis in normolipemic swine.
Why the study?
Does high-dose vitamin D3 supplementation induce coronary atherosclerosis in normolipemic swine?
Does high-dose vitamin D3 supplementation induce coronary atherosclerosis in normolipemic swine?
High-dose vitamin D3 supplementation induces dose-dependent coronary atherosclerosis in normolipemic swine, providing a morphological model resembling human disease.
May caution high-dose vitamin D3 use clinically; leaves open translation of swine lesions to human risk.
Coronary atherosclerosis developed in normolipemic swine fed a basal ration supplemented with 125,000 IU, 62,500 IU and 31,250 IU of vitamin D3/kg of diet for 3 months and subsequently only the basal ration for the following 3 months. Lesions consisted of intimal atheromata and calcified internal elastica and caused luminal narrowing. The incidence of atherosclerotic lesions was proportional to the vitamin D3 doses. The present experimentally induced lesions had many morphological features resembling those in coronary arteries from human subjects.
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Taura et al. (1979) studied Coronary atherosclerosis (n=46). Vitamin D3 vs. Basal ration (387 IU/kg) was evaluated on Incidence of coronary atherosclerotic lesions. High-dose vitamin D3 supplementation (31,250 to 125,000 IU/kg) followed by withdrawal induced coronary atherosclerosis in normolipemic swine, with lesions resembling human disease.
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