SUMMARY Serum and milk concentrations of 9 tetracycline analogues, i.e., tetracycline, oxytetracycline, chlortetracycline, demethylchlortetracycline, methacycline, doxycycline, minocycline, pyrrolidinomethyltetracycline, and tetracycline-l-methyl lysine, were determined in lactating cows and ewes given a single intravenous (iv) injection (20 mg/kg). Oxytetracycline and tetracycline were estimated on the basis of the 2-compartment open model to occupy the largest distribution volumes, (V′D); the smallest V′D, were obtained for pyrrolidinomethyltetracycline and tetracycline-l-methyl lysine. The most lipophilic analogues, i.e., doxycycline, methacycline, and minocycline, were recovered in the greatest amounts in the milk after iv injection and attained the highest ratios of milk-to-serum ultrafiltrate concentrations during equilibrium.
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Gan‐Or et al. (1974) studied this question.