⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 31, 2007Organic Letters

Chlorahololides A and B, Two Potent and Selective Blockers of the Potassium Channel Isolated fromChloranthus holostegius

Sheng‐Ping Yang Zhaobing Gao Fang‐Dao Wang Shang‐Gao Liao Huadong Chen Chuan‐Rui Zhang Guo‐Yuan Hu Jian‐Min Yue

View at Publisher

Ask AI

Bookmark

Share

Abstract

[structure: see text] Chlorahololides A(1) and B(2), two highly complex sesquiterpenoid dimers, were isolated from Chloranthus holostegius. Their structures and absolute configurations were established by NMR spectroscopy, X-ray crystallography, and CD. Chlorahololides A (1) and B (2) exhibited potent and selective inhibition on the delayed rectifier (IK) K+ current, with an IC50 of 10.9 and 18.6 microM, respectively.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Yang et al. (2007) studied this question.

synapsesocial.com/papers/6aa5f95c66012019823a55c3 https://doi.org/10.1021/ol0700759

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 related papers. Consider them for comparative context:

1First Direct Evidence in Biological Diels-Alder Reaction of Incorporation of Diene-Dienophile Precursors in the Biosynthesis of SolanapyronesOriginal Research · 1994 · 82 citations
2Dual PCET-Enabled Chemoselective Decarboxylative Sulfinylation with N -Sulfinyl Phthalimides as Bench-Stable Sulfinyl Radical PrecursorsOrganic Letters · Wed,
3LaCl3-Enabled Synthesis of 2′- C -Substituted Galidesivir AnaloguesOrganic Letters · Wed,
4Nickel-Catalyzed Enantioselective Carbo-Carbonylation of Alkenes Using Formic Acid as a CO Surrogate: Access to Oxindoles Bearing Chiral Quaternary CarbonOrganic Letters · Wed,
5Catalytic Substrate- and Site-Selective TransesterificationOrganic Letters · Wed,

More from Organic Letters

S -Arylsulfinamides via Photoredox-Catalyzed Arylation of N -Sulfinylamines with Diaryliodonium SaltsWed,
Visible-Light-Mediated Skeletal Editing of Furans to N -AminopyrrolesThu,
Thermal EDA-Mediated Divergent Synthesis of Acetimidates and Benzochromenes via a One-Pot Three-Component ReactionThu,
Ruthenium-Catalyzed Site-Selective Direct Deuteration of Azaarenes Using Deuterium OxideThu,
Photocatalytic Formal [4 + 2] Radical Annulation of α-Bromoacetylindoles with Alkenes: Broad Scope and Synthesis of (±)-GoniomitineThu,