Key result
r-hirudin enables cardiopulmonary bypass without thrombotic or coagulopathic complications in a patient with heparin-induced rash.
Why the study?
Does r-hirudin prevent thrombotic or coagulopathic complications when used as an anticoagulant for cardiopulmonary bypass in a patient with heparin intolerance?
Case Report (n=1)
Does r-hirudin prevent thrombotic or coagulopathic complications when used as an anticoagulant for cardiopulmonary bypass in a patient with heparin intolerance?
r-hirudin can be successfully used as an alternative anticoagulant for cardiopulmonary bypass in patients who cannot tolerate unfractionated heparin.
r-Hirudin may be feasible for CPB in heparin-intolerant patients; hypothesis-generating and should not yet change practice.
A 68-year-old woman with unstable angina and an episode of ventricular fibrillation developed a persistent and recurrent rash due to heparin. Medical therapy was continued with danaproid. For cardiopulmonary bypass and coronary artery grafting, r-hirudin was used as the anticoagulant. There were no thrombotic or coagulopathic complications. There is still no ideal alternative to unfractionated heparin for anticoagulation for cardiopulmonary bypass. The use of r-hirudin was successful and we describe our anticoagulant strategy.
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Renee Cameron (2001) conducted a case report in Unstable angina and heparin-induced rash requiring cardiopulmonary bypass (n=1). r-hirudin was evaluated on Thrombotic or coagulopathic complications. The use of r-hirudin as an anticoagulant for cardiopulmonary bypass in a patient with heparin-induced rash was successful with no thrombotic or coagulopathic complications.
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