Key result
IGF-I and IGFBP-3 measurements help identify primary IGF deficiency in children with suspected GH-IGF defects.
The paper proposes defining 'Primary IGF deficiency' as decreased IGF-I production with normal GH secretion, emphasizing IGF-I and IGFBP-3 measurements in pediatric work-ups.
• The GH-IGF system should be viewed like other endocrine systems, with a central, trophic hormone (GH) and a peripherally active hormone (IGF-I). • A decrease in IGF-I production, without a concomitant impairment in GH secretion, should be termed 'Primary IGF deficiency'. • IGF-I and IGFBP-3 measurements should be given precedence in the work-up of children with suspected defects of the GH-IGF axis. • The terms 'GH insensitivity' and 'IGF-I deficiency' are not identical terms. To define a disease condition in terms of its lack of response to treatment is conceptually misleading.
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Michael B. Ranke (2006) conducted an editorial in Insulin-Like Growth Factor-I Deficiency. A decrease in IGF-I production without impaired GH secretion should be termed 'Primary IGF deficiency', and IGF-I/IGFBP-3 measurements should be prioritized in children with suspected GH-IGF defects.
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