Key result
Nifedipine shortens time to peak propranolol concentration by ~1 hour without affecting metoprolol or atenolol.
Why the study?
Does nifedipine affect the pharmacokinetics and pharmacodynamics of propranolol, metoprolol, and atenolol in healthy volunteers?
Does nifedipine affect the pharmacokinetics and pharmacodynamics of propranolol, metoprolol, and atenolol in healthy volunteers?
Answers are grounded in this paper and cite their sources.
Concomitant use of nifedipine and lipophilic beta-blockers does not result in clinically significant pharmacokinetic or pharmacodynamic interactions.
The influence of chronic therapy with nifedipine on the pharmacokinetics of propranolol 80 mg twice daily, metoprolol 100 mg twice daily and atenolol 100 mg once daily was investigated in eight healthy volunteers. Nifedipine 10 mg three times daily did not affect the pharmacokinetics of metoprolol and atenolol whereas nifedipine shortened the time to peak plasma concentration for propranolol by about 1 h. Propranolol, metoprolol and atenolol provoked comparable decreases in heart rate measured at rest and during exercise. The beta-adrenoceptor blocking properties of propranolol, metoprolol and atenolol were not affected by concomitant therapy with nifedipine. The present study did not show significant pharmacokinetic and pharmacodynamic interactions between nifedipine and lipophilic beta-adrenoceptor blockers.
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Gangji et al. (1984) studied Healthy volunteers (n=8). Nifedipine was evaluated on Pharmacokinetics and pharmacodynamics of propranolol, metoprolol and atenolol. Nifedipine did not affect the pharmacokinetics of metoprolol and atenolol, but shortened the time to peak plasma concentration for propranolol by about 1 hour.
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