Screening for Cystic FibrosisSir,In their Short Report on screening for cystic fibrosis, Vol.47, pages 131-134, Drs.Cain, Deall, and Noble expressed the hope that their trial would stimulate other maternity units to carry out similar surveys so that the efficiency of the method could be more rapidly assessed.In 1969 we started developing an immunochemical method to analyse meconium for albumin, and since August 1971 we have conducted a screening programme for CF in newborns at the University Hospital, Uppsala, Sweden.So far 2073 newborn infants have been screened and two cases of CF have been found.A specimen of meconium is collected from the napkin, freeze-dried, and an aliquot is dissolved.After centri- fugation the concentration of albumin in the supernatant is determined by single radial immunodiffusion technique.The results are given in the Table.
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Kollberg et al. (1972) studied this question.