Key result
Geographic region is linked to significant variations in European cerebrovascular and heart disease mortality.
Observational
This 1964 ecological study suggests a potential link between environmental and dietary factors, specifically calcium and vitamin deficiencies, and cerebrovascular mortality in Europe.
Regional mortality patterns may reflect modifiable dietary factors; leaves open causal confirmation in contemporary prospective cohorts.
For an epidemiologic approach to the etiology of cerebrovascular disease by comparing with that of arteriosclerotic and degenerative heart diseases, the latest regional data for mortality from those diseases were collected from most European countries in 1964. The peculiar gradient of the mortality rate distribution in the respective countries is interpreted by physicochemical factors of natural environment such as climate, geology and character of water, and the socio-economic factors such as urban-rural residency, status of agriculture and indus-trialization, and local dietary habits. As a result, the effect of calcium and vitamin deficiencies is epidemiologically suggested for the development of cerebro-vascular disease.
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Eiji Takahashi (1967) conducted an observational in Cerebrovascular disease and arteriosclerotic and degenerative heart disease. Geographic location and environmental factors vs. Other geographic regions was evaluated on Geographic distribution of mortality rates from cerebrovascular disease and arteriosclerotic and degenerative heart disease. Regional mortality rates for cerebrovascular and arteriosclerotic heart diseases varied significantly within and across European countries, suggesting potential influences of environmental, dietary, and socioeconomic factors.
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