Key result
Acute mesenteric ischemia is linked to a ~78% higher prevalence of prothrombotic disorders versus healthy controls.
Why the study?
Is there a higher prevalence of prothrombotic abnormalities in patients with acute mesenteric ischemia compared to healthy controls?
Case-Control (n=131)
Is there a higher prevalence of prothrombotic abnormalities in patients with acute mesenteric ischemia compared to healthy controls?
Absolute Event Rate: 57% vs 32%
p-value: p=0.020
Prothrombotic disorders, particularly Factor V Leiden, are significantly more prevalent in patients with acute mesenteric ischemia and may be a predisposing factor.
May support targeted thrombophilia evaluation in acute mesenteric ischemia; leaves open impact on outcomes or management.
Acute mesenteric ischemia (AMI) is a rare condition that may be associated with a variety of congenital prothrombotic disorders (PDs). The purpose of this study was to assess the prevalence of these disorders in 28 AMI patients compared with 103 healthy individuals from the northeastern region of Turkey. They were screened for protein C, antithrombin III, and protein S deficiencies; and gene analysis was performed using the polymerase chain reaction. A PD was revealed in 16 (57%) patients and 33 (32%) controls (p = 0.020). Factor V Leiden (FVL), prothrombin G20210A mutation, and TT677 homozygous mutation of methylenetetrahydrofolate reductase was detected in 10 (36%) patients versus 16 (15%) controls (p = 0.035), 3 (11%) patients versus 10 (9%) controls (p = 1.00), and 1 (3%) patient versus no controls, respectively. Consistent with caucasian ethnic groups, there was high prevalence of PDs, especially FVL; and these abnormalities might be a significant predisposing factor in the pathogenesis of AMI.
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Agaoglu et al. (2005) conducted a case-control in Acute mesenteric ischemia (n=131). Acute mesenteric ischemia vs. Healthy individuals was evaluated on Presence of a prothrombotic disorder (p=0.020). Prothrombotic disorders were significantly more prevalent in patients with acute mesenteric ischemia compared to healthy controls (57% vs 32%; p=0.020).
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