In vivo Sedative and Anxiolytic Potential in Mice for Methanolic Extract of Tinospora cordifolia

Background and Objective: Tinospora cordifolia (Willd.)Hook.f. is employed in Ayurvedic system of medicine for the treatment of diabetes, jaundice, rheumatoid arthritis, metabolic disorders and likewise utilized as memory enhancer.In this study it tend to analyze in vivo sedative and anxiety potential in mice for T. cordifolia stems extracted in methanol.Materials and Methods: The crude extract of T. cordifolia was evaluated for its central nervous system depressant effect using rodent behavioral models; such as ʻHole cross testʼ and ʻOpen field testʼ for its sedative properties and an ʻElevated plus maze testʼ for its anxiolytic potential.Results: In sedative study, the extract at a dose of 200 and 400 mg kgG 1 b.wt.showed a dose-dependent and statistically significant (p<0.05-0.01)suppression of motor activity and exploratory activity of the mice in both open field and hole cross test.The extract also showed increased percentage of entry into open arms at both doses in anxiolytic potential study.At a dose of 400 mg kgG 1 b.wt.maximum anxiolytic activity (p<0.001) was found which was comparable to the standard Diazepam.Conclusion: This study unconcealed that the methanolic extract of Tinospora cordifolia has significant central nervous system depressant impact.More studies on active constituent of the extract will give approaches for therapeutic intervention.