Key result
Vacuum-assisted closure promotes poststernotomy mediastinitis healing but hemodynamic effects require caution for vulnerable bypass grafts.
This review summarizes the current understanding of how vacuum-assisted closure promotes wound healing and affects cardiopulmonary function in patients with poststernotomy mediastinitis.
Requires hemodynamic vigilance during vacuum-assisted closure in poststernotomy mediastinitis; leaves open prospective cardiopulmonary outcome trials.
SUMMARY: : Vacuum-assisted closure has been adopted as the first-line treatment for poststernotomy mediastinitis as a result of the excellent clinical outcome achieved with its use. Scientific evidence regarding the mechanisms by which vacuum-assisted closure promotes wound healing has started to emerge, although knowledge regarding the effects on heart and lung function is still limited. The organs in the mediastinum are hemodynamically crucial, and in patients with poststernotomy mediastinitis, vulnerable bypass grafts and reduced cardiac function must be taken into consideration during vacuum-assisted closure therapy. This article provides an overview of the effects of vacuum-assisted closure on heart and lung function and summarizes the current knowledge on the mechanisms by which vacuum-assisted closure therapy promotes wound healing.
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Malmsjö et al. (2007) conducted a review in Poststernotomy mediastinitis. Vacuum-assisted closure was evaluated. Vacuum-assisted closure promotes wound healing in poststernotomy mediastinitis, though its hemodynamic effects on heart and lung function require careful consideration of vulnerable bypass grafts.
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