Intramolecular Ritter reactions of 2‐(2‐cyanoethyl)tetrahydrocyclopenta[b]indole and ‐carbazole derivatives, prepared by a sequence of two different α‐substitutions and Grignard reactions of the indole‐based ketones 4‐methyl‐1,4‐dihydrocyclopenta[b]indol‐3(2H)‐one and 9‐methyl‐2,3,4,9‐tetrahydro‐1H‐carbazol‐1‐one, were used as key steps in the construction of various tetracyclic lactam compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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Maertens et al. (2004) studied this question.
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