Mometasone furoate cream 0.1% vs. hydrocortisone cream 1% in the treatment of seborrhoeic dermatitis

The safety and efficacy of mometasone furoate cream 0.1% (applied once daily), and hydrocortisone cream 1% (applied twice. daily) were compared in a 6-week multicentre, randomized, third-party-blind, trial in 117 seborrhoeic dermatitis patients. Most patients were cleared of disease signs and symptoms during the first 3 weeks of treatment. The mometasone-treated patients showed a 93% improvement in disease sign/symptom scores vs. 85% improvement among hydrocortisone-treated patients (P<0.05). Transient signs of skin atrophy were observed after the third week of treatment, which was beyond the period of the drug's therapeutic effect.