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Maximal acid output (M.A.O.) and intrinsic factor (I.F.) of the stomach were measured in 16 patients with polycythaemia vera, 4 of whom had a duodenal ulcer and 2 pernicious anaemia. It was found that, in general, the M.A.O. was significantly less than normal unless an active duodenal ulcer was present when the M.A.O. would reach the usual levels for duodenal ulcer subjects. The gastric I.F. output showed a significant correlation with the M.A.O. These results are discussed in the light of the increased incidence of peptic ulcer in polycythaemia vera and the occasionally reported cases of polycythaemia vera and pernicious anaemia.
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Hume et al. (1968) studied this question.
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