Key result
High adiponectin shows no association with CVD risk versus low levels in T2D.
Why the study?
Is higher adiponectin concentration associated with a reduced risk of cardiovascular disease in patients with diabetes mellitus?
Meta-Analysis
Is higher adiponectin concentration associated with a reduced risk of cardiovascular disease in patients with diabetes mellitus?
Relative Risk: 0.99 (95% CI 0.67–1.45)
This meta-analysis found no significant association between adiponectin levels and cardiovascular disease risk in patients with diabetes.
Adiponectin levels should not guide CVD risk assessment in type 2 diabetes; leaves open questions on confounding and causality.
BACKGROUND: This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM). METHODS: PubMed and Embase were searched for prospective studies on the association of adiponectin concentrations and risk of CVD up to June 2013. Random-effect model was selected to pool the relative risk (RR) and 95% CI. RESULTS: Five prospective cohort studies and one nested case-control studies met the included criterion. The estimated summary RR and 95% CI of five prospective cohort studies for type 2 diabetes comparing top vs low tertile of adiponectin concentrations was 0.99 (95% CI: 0.67-1.45), with significant heterogeneity between studies (p = 0.037, I (2) = 60.9%). This heterogeneity was explained by one study conducted in Korean. CONCLUSIONS: This study represents the first meta-analysis between adiponectin levels and CVD in diabetic patients and indicated no association was found. This result should be verified further by large sample size, long duration of follow-up, and well-designed prospective clinical trials.
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Wu et al. (2013) conducted a meta-analysis in Diabetes mellitus. Top tertile of adiponectin concentrations vs. Low tertile of adiponectin concentrations was evaluated on Cardiovascular disease (CVD) (RR 0.99, 95% CI 0.67-1.45). Top versus low tertile of adiponectin concentrations was not associated with cardiovascular disease risk in patients with type 2 diabetes (RR 0.99; 95% CI 0.67-1.45).
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