Key result
General anesthesia linked to ~210% higher one-year mortality in patients with femoral neck fractures.
Observational (n=185)
No
Odds Ratio: 3.1 (95% CI 1.1–8.5)
p-value: p=0.028
Patients presenting with a fractured neck of femur have persistently high morbidity and mortality, with age >90, general anaesthesia, ASA score, and post-operative oliguria being significant predictors of one-year mortality.
General anaesthesia was associated with higher one-year mortality after neck-of-femur fracture; randomized trials are needed to confirm causality and inform practice.
OBJECTIVES: To determine the morbidity and mortality outcomes of patients presenting with a fractured neck of femur in an Australian context. Peri-operative variables related to unfavourable outcomes were identified to allow planning of intervention strategies for improving peri-operative care. METHODS: We performed a retrospective observational study of 185 consecutive adult patients admitted to an Australian metropolitan teaching hospital with fractured neck of femur between 2009 and 2010. The main outcome measures were 30-day and one-year mortality rates, major complications and factors influencing mortality. RESULTS: The majority of patients were elderly, female and had multiple comorbidities. Multiple peri-operative medical complications were observed, including pre-operative hypoxia (17%), post-operative delirium (25%), anaemia requiring blood transfusion (28%), representation within 30 days of discharge (18%), congestive cardiac failure (14%), acute renal impairment (12%) and myocardial infarction (4%). Mortality rates were 8.1% at 30 days and 21.6% at one year. Factors predictive of one-year mortality were American Society of Anesthesiologists (ASA) score (odds ratio (OR) 4.2 (95% confidence interval (CI) 1.5 to 12.2)), general anaesthesia (OR 3.1 (95% CI 1.1 to 8.5)), age > 90 years (OR 4.5 (95% CI 1.5 to 13.1)) and post-operative oliguria (OR 3.6 (95% CI 1.1 to 11.7)). CONCLUSIONS: Results from an Australian metropolitan teaching hospital confirm the persistently high morbidity and mortality in patients presenting with a fractured neck of femur. Efforts should be aimed at medically optimising patients pre-operatively and correction of pre-operative hypoxia. This study provides planning data for future interventional studies. Cite this article: Bone Joint Res 2013;2:162-8.
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Chia et al. (2013) conducted an observational in Fractured neck of femur (n=185). General anaesthesia vs. Neuraxial anaesthesia was evaluated on One-year mortality (OR 3.1, 95% CI 1.1-8.5, p=0.028). In patients admitted with a fractured neck of femur, general anaesthesia was identified as a significant independent predictor of one-year mortality (OR 3.1).
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