Synthesis of pyridyl‐ and quinolyl‐substituted 2‐aminothiazoles

Five 2‐amino‐4‐(x‐pyridyl)‐ and 2‐amino‐4‐(x‐quinolyl)thiazoles have been synthesized by the condensation of thiourea with bromoacetylpyridines and ‐quinolines. The reaction of pyridyl pyridylmethyl ketones with thiourea and halogens produced four 2‐aminothiazoles possessing pyridyl substituents in 4‐ and 5‐positions on the thiazole ring. Treatment of N‐(3‐pyridyl)‐ and N‐(3‐quinoiyl)thiourea with α‐bromoketones gave seven new 2‐(3‐pyridyl)amino‐ and 2‐(3‐quinolyl)aminothiazoles. The ultraviolet spectra of the pyridyl‐ and quinolyl‐ substituted 2‐aminothiazoles were recorded.