Key result
KATP SNP rs1799858 T-allele linked to ~190% higher AMI risk versus CC genotype.
Why the study?
Whether ATP-sensitive potassium channel genetic variants predict increased LDL-C concentration and the risk of macro- and micro-vascular arteriosclerotic events remained elusive.
Does the KATP SNP rs1799858 predict increased LDL-C concentration and risk of macro-/micro-vascular arteriosclerotic events?
Observational (n=640)
Does the KATP SNP rs1799858 predict increased LDL-C concentration and risk of macro-/micro-vascular arteriosclerotic events?
The KATP SNP rs1799858 is associated with increased LDL-C levels and a higher risk of macro- and micro-vascular arteriosclerotic events, including acute myocardial infarction.
Should not yet change AMI risk stratification; leaves open whether rs1799858 adds value beyond LDL-C monitoring.
BACKGROUND: Plasma concentration of low-density lipoprotein cholesterol (LDL-C) is causally related to the risk of arteriosclerotic events. Whether ATP-sensitive potassium channels (KATP) genetic variants predict increased LDL-C concentration (≥1.8 mmol/L) and risk of macro-/micro-vascular arteriosclerotic event remain elusive. METHODS: A total of 320 subjects with increased LDL-C concentration (≥1.8 mmol/L) and 320 counterpart subjects (< 1.8 mmol/L) from the South China were enrolled in this study. Three KATP polymorphisms (rs1799858, rs4148671 and rs78148713) were genotyped by the Sequenom MassARRAY system. Binary logistic regression analysis was used to evaluate the association of the 3 KATP variants with increased LDL-C concentration and carotid artery stenosis (CAS) ≥50%. Two-way ANOVA was used to analyze the association of the 3 KATP variants with microalbumin in urine (MAU) and high-sensitivity C-reactive protein (HsCRP) levels. Cox proportional hazards regression analysis was used to retrospectively analyse the association of the optimal variant with the risk of new onset/recurrent acute myocardial infarction (AMI). RESULTS: Among the 3 studied KATP gene single nucleotide polymorphisms (SNPs), only rs1799858 (TT + CT genotype) was associated with elevated risk of LDL-C ≥ 1.8 mmol/L (adjusted OR = 2.25, 95% CI: 1.31-3.85, P = 0.003) and CAS ≥50% (adjusted OR = 2.80, 95% CI: 1.12-6.98, P = 0.028). KATP SNP rs1799858 was also associated with increased MAU (P = 0.013) and HsCRP (P = 0.027) levels. The follow-up for an average of 51.1-months revealed that participants carrying the T-allele (TT + CT) of rs1799858 was associated with high risk of new onset/recurrent AMI (adjusted HR = 2.90, 95% CI: 1.06-7.94, P = 0.038). CONCLUSION: The KATP SNP rs1799858 may be an optimal genetic predisposition marker for increased LDL-C concentration (≥1.8 mmol/L) and its related macro-/micro-vascular arteriosclerotic event risk. The KATP variant rs1799858 was associated with higher risk of macro-/micro-vascular arteriosclerotic events in patients with elevated serum LDL-C levels.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2020) conducted an observational in Increased low-density lipoprotein cholesterol levels (≥1.8 mmol/L) (n=640). KATP gene polymorphism rs1799858 (TT + CT genotype) vs. CC genotype was evaluated on New onset/recurrent acute myocardial infarction (AMI) (HR 2.90, 95% CI 1.06-7.94, p=0.038). Participants carrying the T-allele (TT + CT) of the KATP SNP rs1799858 had a significantly higher risk of new-onset or recurrent acute myocardial infarction (HR 2.90) compared to those with the CC genotype.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: