A good imitation: Aryl-1-indanyl ketones are found to be highly efficient, reversible, cell-penetrating inhibitors of the human peptidyl prolyl cis/trans isomerase Pin1. Owing to their structure 1, they are assumed to mimic the transition state 2 of the enzymatically catalyzed rotation about the imidic peptide bond preceding a proline residue.
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Daum et al. (2006) studied this question.
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