Key result
Plateletworks analyzer demonstrates acceptable accuracy and correlation with central laboratory analyzers for blood cell counts.
Why the study?
Does the Plateletworks® BC 3200 automated hematology analyzer provide accurate and precise blood cell counts compared to a central laboratory analyzer in cardiac surgical patients?
Observational (n=115)
No
Does the Plateletworks® BC 3200 automated hematology analyzer provide accurate and precise blood cell counts compared to a central laboratory analyzer in cardiac surgical patients?
Effect estimate: r = 0.97-0.99
The Plateletworks® point-of-care hematology analyzer provides acceptable precision and accuracy for blood cell counts compared to standard central laboratory analyzers, supporting its use in cardiac surgery settings.
POCT platelet testing needs lab validation before cardiac surgery use; leaves open whether performance supports routine adoption.
Prior to undergoing cardiac surgery many patients may have impaired platelet function due to platelet inhibition. Point of care testing (POCT) that produces quick results of platelet counts and function allow earlier clinician interpretation, diagnosis and treatment. Before being adopted for routine clinical use, a POCT device's performance must be evaluated by standard laboratory techniques to ensure high quality results. The purpose of this study is to determine the performance of the Plateletworks?V BC 3200 automated hematology analyzer by correlating its precision, accuracy and linearity for the measurement of blood counts to our hospital central laboratory analyzer (Beckman Coulter Unicel DXH 800). The study utilizes well described methods for Within-Run and Day-to-Day precision, comparison of methods (bias), and linearity. Control samples from the manufacturer were used for the precision studies, blood samples from 115 cardiac surgical subjects were used for comparison of methods and accuracy, and pre-diluted control samples from the manufacturer were used for the linearity studies. The precision of the Plateletworks® analyzer was acceptable. The overall coefficient of variation (CV) for the measured parameters at all levels of control for Within-Run precision was acceptable ranging from 0.65-6.4%. Likewise, the CV for the measured parameters at all levels of control for Day-to-Day precision was acceptable ranging from 1.45% to 6.7%. The correlation and accuracy between the two analyzers for the evaluated parameters (platelets, red blood cells, white blood cells, and hemoglobin) was acceptable. The linearity for the measured parameters was also acceptable with a range between 98-100%. The performance of the Plateletworks® analyzer was acceptable for providing blood cell counts as compared to our central hospital laboratory analyzer.
No takes yet. Share an insight, caveat, or question.
McNair et al. (2015) conducted an observational in Cardiac surgery (n=115). Plateletworks BC 3200 automated hematology analyzer vs. Beckman Coulter Unicel DXH 800 was evaluated on Correlation and accuracy of measured blood cell counts (PLT, WBC, RBC, Hgb) (r = 0.97-0.99). The Plateletworks analyzer demonstrated acceptable correlation (r = 0.97-0.99) and accuracy for measuring blood cell counts compared to the central hospital laboratory analyzer.