The antitumor and antimalarial activity of fish oils may involve the action of phospholipid hydroperoxides. Two such phosphatidylcholines, 1 and 2, bearing the hydroperoxides of docosahexaenoic and eicosapentaenoic acids—the two major fatty acids in fish oils—have been synthesized. In spite of its high degree of unsaturation, 1 is sufficiently stable to permit its use in biological studies.
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Onyango et al. (2001) studied this question.
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