Key result
Higher NT-proBNP in hemodialysis patients correlates with lower lipid levels and longer dialysis duration.
Why the study?
The association of NT-proBNP with demographic, clinical, and biochemical factors in hemodialysis patients remains unclear.
Cross-Sectional (n=78)
No
Effect estimate: r=-0.348
p-value: p=0.002
In hemodialysis patients, NT-proBNP levels are significantly associated with lipid profiles, ferritin, ALP, and duration of hemodialysis, suggesting a potential prognostic role.
Associations with lipids and ferritin should not change practice; hypothesis-generating for NT-proBNP prognostic value in hemodialysis.
Introduction: Introduction: N-terminal pro-B type natriuretic peptide (NT-proBNP) can be used to diagnose cardiac and renal disease. The association of NT-pro BNP with demographic, clinical and biochemical factors in hemodialysis is unclear. Objectives: This study aimed to examine association of NT-pro BNP and mentioned factors in hemodialysis patients. Patients and Methods: This study was conducted on 78 end-stage renal disease (ESRD) patients under hemodialysis. Demographic data, lipid profile and electrolytes were recorded. NT-proBNP was checked simultaneously and its association with mentioned factors were assessed. Results: The average NT-pro BNP level was 890.52±700.87 pg/mL (range: 0.1-3343 pg/mL). Serum level of NT-pro BNP was statistically in association with total cholesterol (P=0.002; r=-0.348), low density lipoprotein (LDL) (P=0.09; r= -0.292), high density lipoprotein (HDL) (P=0.06; r=-0.310) and serum triglyceride (P=0.018; r=-0.269) while having a direct relationship with serum ferritin (P=0.022; r=0.274), alkaline phosphatase (ALP) (P=0.048; r=0.224) and duration of hemodialysis (P=0.005; r=0.321). Conclusion: Lipid profile and ferritin are associated with NT-pro BNP levels. This can reflect possible prognostic role of NT-proBNP among ESRD patients on hemodialysis.
No takes yet. Share an insight, caveat, or question.
Bonakdar et al. (2019) conducted a cross-sectional in End-stage renal disease (ESRD) under hemodialysis (n=78). Clinical and biochemical factors (e.g., lipid profile, ferritin, ALP) was evaluated on Association of NT-proBNP with total cholesterol (r=-0.348, p=0.002). Serum NT-proBNP levels in hemodialysis patients were significantly inversely associated with total cholesterol, LDL, HDL, and triglycerides, and positively associated with ferritin, alkaline phosphatase, and hemodialysis duration.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: