Highly selective for (R)-hydroperoxides (R)-1, horseradish peroxidase (HRP) is used for the kinetic resolution of racemic 1 furnishing (R)-2 alcohols and enantiomerically pure hydroperoxides, which are difficult to prepare by nonenzymatic means. This transformation carried out in the presence of guaiacol [Eq. (a)] can be conducted on a preparative scale. R1 Ph, C(CH2)CO2Me; R2 Me, Et.
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Adam et al. (1993) studied this question.
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