Why the study?
Although exenatide protects cardiomyocytes against hypoxia/reoxygenation injury and enhances glucose uptake, the relationship between these two effects and the underlying signaling pathway remained unclear.
Does exenatide improve cell vitality and glucose uptake in H9c2 cells subjected to hypoxia/reoxygenation?
Does exenatide improve cell vitality and glucose uptake in H9c2 cells subjected to hypoxia/reoxygenation?
p-value: p=<0.05
Exenatide protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury and promotes glucose uptake specifically via the p38MAPKγ pathway.
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Khalil et al. (2021) studied Hypoxia/reoxygenation-induced cardiomyocyte damage. Exenatide (Ex-4) vs. Control group (NC group) and inhibitor groups (SB203580, BIRB796) was evaluated on Cell vitality and glucose uptake (p=<0.05).
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