August 5, 2011European Journal of Cardio-Thoracic Surgery
The elusive link between aortic wall histology and echocardiographic anatomy in bicuspid aortic valve: implications for prophylactic surgery
Key result
Indexed aortic annulus diameter linked to ~12-fold higher odds of moderate-to-severe aortic wall abnormalities.
- OR 12.22
- 95% CI 1.65-90.38
- P=0.014
- n=127
Why the study?
Do clinical and echocardiographic findings predict histological abnormalities of the aortic wall in patients with bicuspid aortic valve undergoing aortic surgery?
Population
127 patients with bicuspid aortic valve and a wide spectrum of valvar disease who underwent replacement of…
Design
Cohort
Authors
Discussion
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Member takes
Implication
Indexed annulus diameter may flag wall abnormalities in bicuspid valve surgery; leaves open prospective validation for risk stratification.
Study Design
Type
Cohort (n=127)
Structured PICO
Do clinical and echocardiographic findings predict histological abnormalities of the aortic wall in patients with bicuspid aortic valve undergoing aortic surgery?
P
Population
127 patients with bicuspid aortic valve undergoing replacement of the ascending aorta, assessed for clinical and echocardiographic predictors of histological abnormalities.
E
Exposure
Clinical and echocardiographic assessment (specifically indexed diameter of the aortic annulus)
O
Outcome
Histological abnormalities of the aortic wall (classified using a 5-grade system developed by Larson and Edward)surrogate
Main Result
Odds Ratio: 12.22 (95% CI 1.65–90.38)
p-value: p=0.014
A high proportion of patients with bicuspid aortic valve and mild to moderate aortic dilatation have severe histological abnormalities of the aortic wall that are not predictable by standard clinical and echocardiographic findings, highlighting the need for better risk stratification tools.
Cite This Study
Leone et al. (2011) conducted a cohort in Bicuspid aortic valve (n=127). Indexed diameter of the aortic annulus was evaluated on Moderate/severe (grade 2-3) histological alterations of the aortic wall (OR 12.22, 95% CI 1.65-90.38, p=0.014). The indexed diameter of the aortic annulus was significantly associated with moderate to severe histological abnormalities of the aortic wall (OR 12.22; 95% CI 1.65-90.38; p=0.014).