Key result
Intracoronary streptokinase reduces TXA-2 levels versus saline in a canine model without increasing PGI-2.
Why the study?
Does intracoronary streptokinase infusion alter prostacyclin and thromboxane A2 levels in a canine model?
Population
Canine model (n=20)
Comparison
Left coronary artery infusion of normal saline vs Left coronary artery infusion of 50,000 units…
Design
Preclinical
Follow-up
90 minutes of infusion plus postinfusion sampling
Authors
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Streptokinase lacks PGI-2 mediation in canines; leaves open competing TXA-2 effects for human translation.
Does intracoronary streptokinase infusion alter prostacyclin and thromboxane A2 levels in a canine model?
p-value: p=.001 < P < .01
In a canine model, intracoronary streptokinase does not appear to mediate beneficial effects via PGI-2, and fibrinolytic infusions may produce competing effects of thrombolysis and endothelial injury with TXA-2 production.
Becker et al. (1986) studied Canine model (n=20). Intracoronary streptokinase (SK) vs. Normal saline was evaluated on Plasma levels of prostacyclin (PGI-2) and thromboxane (TXA-2) (p=.001 < P < .01). Intracoronary streptokinase infusion in a canine model did not increase PGI-2 levels, whereas TXA-2 levels were significantly higher in saline-infused animals than in SK-infused controls (P<0.01).
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