Approximate Insulin Content of Extemporaneous Mixtures of Insulin and Protamine Zinc Insulin

Article1 February 1943APPROXIMATE INSULIN CONTENT OF EXTEMPORANEOUS MIXTURES OF INSULIN AND PROTAMINE ZINC INSULINFRANKLIN B. PECK, M.D., F.A.C.P.FRANKLIN B. PECK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-2-177 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe number of possible modifications of insulin is almost unlimited. Within the last few years several new preparations have been described1, 2, 3and each has seemed to possess certain more or less specific advantages.4, 5, 6Nevertheless, in common with protamine zinc insulin these modifications must of necessity be prepared with definite proportions of ingredients so each has its own individual time-activity, with onset and duration of physiologic action constant for each fixed combination. Each of these modifications provides a curve of time-activity which fits the needs of a limited group of diabetic patients almost perfectly.6But judging from...References1. BISCHOFF F: Histone combinations of the protein hormones, Am. Jr. Physiol., 1936, cxvii, 182-187. CrossrefGoogle Scholar2. REINERSEARLELANG LDSEH: Insulin preparations with prolonged activity, I. Globin insulin, Proc. Soc. Exper. Biol. and Med., 1939, xl, 171. CrossrefGoogle Scholar3. WARVEL JH: Protamine and other slow acting insulins and their clinical application, Review of medical progress, Ohio State Univ. Coll. of Med., 1940, p. 140. Google Scholar4. BAUMAN L: Clinical experience with globin insulin, Am. Jr. Med. Sci., 1939, cxcviii, 475-481. CrossrefGoogle Scholar5. BARNESCUTTLEDUNCAN CATDGG: Histone zinc insulin—its pharmacologic characteristics and its application in the treatment of diabetes mellitus, Jr. Pharmacol. and Exper. Therap., 1941, lxxii, 331-343. Google Scholar6. BAILEYMARBLE CCA: Histone zinc insulin, globin (zinc) insulin and clear protamine zinc insulin. A comparative study of their action, Jr. Am. Med. Assoc., 1942, cxviii, 683-690. CrossrefGoogle Scholar7. WILDER RM: Clinical diabetes and hyperinsulinism, 1940, W. B. Saunders Co., Philadelphia, p. 92. Google Scholar8. ULRICH H: Clinical experiments with mixtures of standard and protamine zinc insulin, ANN. INT. MED., 1941, xiv, 1166-1179. Google Scholar9. COLWELLIZZOSTRYKER ARJLWA: Intermediate action of mixtures of soluble insulin and protamine zinc insulin, Arch. Int. Med., 1942, lxix, 931-951. CrossrefGoogle Scholar10. HAGEDORNJENSENKRARUPWODSTRUP HCBNNBI: Protamine insulinate, Acta med. Scandinav., Supp., 1936, lxxviii, 678-684. Google Scholar11. KRARUP NB: Clinical investigations into the action of protamine insulinate, 1935, G. E. C. Gad., Copenhagen. Google Scholar12. GRAHAM G: Use of a mixture of ordinary and protamine insulin, Acta med. Scandinav., Supp., 1938, xc, 54-63. Google Scholar13. LAWRENCE RD: Zinc-protamine-insulin in diabetes: Treatment by one daily injection, Brit. Med. Jr., 1939, i, 1077-1080. CrossrefGoogle Scholar14. WATSON EM: Comparative efficacy of various methods for administering insulin, Canad. Med. Assoc. Jr., 1940, xliii, 444-447. Google Scholar15. WAUCHOPE GM: Zinc protamine insulin and soluble insulin, interaction in combined doses, Lancet, 1940, i, 963-966. Google Scholar16. PECK FB: Action of insulin, Proc. Am. Diabetic Assoc., 1942, ii, 69-83. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Received for publication September 21, 1942.From the Lilly Research Laboratories and Diabetic Clinic, Indianapolis City Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPROCEEDINGS OF THE TWENTYFIRST SCANDINAVIAN CONGRESS FOR INTERNAL MEDICINEInsulin mixturesInsulin mixturesA nomogram for the preparation of insulin-protamine zinc insulin mixturesGlobin insulin: a clinical studyDISORDERS OF THE NEWBORNLIVER NECROSIS AFTER TRILENE ANÆSTHESIAINSULIN MIXTURES 1 February 1943Volume 18, Issue 2Page: 177-181KeywordsHospitalsInsulinProtaminesResearch laboratoriesZinc ePublished: 1 December 2008 Issue Published: 1 February 1943 PDF downloadLoading ...