Clinical Experiments With Mixtures of Standard and Protamine Zinc Insulins

Article1 January 1941CLINICAL EXPERIMENTS WITH MIXTURES OF STANDARD AND PROTAMINE ZINC INSULINSHELMUTH ULRICH, M.D., F.A.C.P.HELMUTH ULRICH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-7-1166 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvanescent action is one of the major disadvantages of standard insulin. Protamine zinc insulin overcomes this difficulty. Its absorption from the site of injection is slow; its therapeutic action is prolonged. But precisely because of its retarded action, short periods of post-prandial hyperglycemia and glycosuria are common with its use. If separate additional injections of standard insulin are given for the purpose of eliminating this objectionable feature, then one of the major advantages of protamine zinc insulin, a reduction in the number of injections, is partly or wholly lost.Mixtures of the two forms of insulin in the same syringe...Bibliography1. CAMPBELLFLETCHERKERR WRAARB: Protamine insulin in the treatment of diabetes mellitus, Am. Jr. Med. Sci., 1936, cxcii, 589. CrossrefGoogle Scholar2. GRAHAM G: The use of a mixture of ordinary and protamine insulin, Acta med. Scand. (Supplement), 1938, xc, 54. Google Scholar3. Queries and Minor Notes, Jr. Am. Med. Assoc., 1939, cxii, 871. Google Scholar4. CAMPBELL WR: Some difficulties in the use of the insulins in diabetic practice, Bull. New York Acad. Med., 1939, xv, 579. Google Scholar5. PECK FB: Personal communication. Google Scholar6. CAMPBELL WR: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 23, 1939.From the Evans Memorial of the Massachusetts Memorial Hospitals, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInsulin Preparations with Prolonged EffectPrepared insulin mixtures in the treatment of the severe diabetic patientInsulin mixturesInsulin mixturesExperience with insulin mixturesCLINICAL TRIAL OF DI-INSULINEffective Insulin Timing in Diabetes MellitusInsulin Mixtures and ModificationsGlobin insulin: a clinical studyDISORDERS OF THE NEWBORNLIVER NECROSIS AFTER TRILENE ANÆSTHESIAINSULIN MIXTURES 1 January 1941Volume 14, Issue 7Page: 1166-1179KeywordsHyperglycemiaInsulinProtaminesZinc ePublished: 1 December 2008 Issue Published: 1 January 1941 PDF downloadLoading ...