Some Experiments with Protamine Insulinate

o a"after the injection of p.entnucleotide 10 c,cm.This amount was given twice daily, and -when the patient was distressed -coramine was injected.-On July 24th there was again a blotchy eraption on the abdomen and lower part of the chest, and some exudate was seen on the posterior pharyngeal wall.The tongue and mouth were very dry and there was some diarrhoea.On the next day dysphagia was marked and the pulse became intermittent.On July 26th a small anal ulcer was seen.The throat sloughs were now very large, covering most of the fauces a,s before.On July 28th Cheyne-Stokes breath-ing was noticed when the patient was asleep.Much offensive sputum was coughed up, suggesting that sloughs were separating further down the pharynx and oesophagus.The report on the sputum was: " Direct examination shows epithelial cells, no pus, many Gram-positive and Gram-negative cocci.Cultures resulted in growths of the following organisms, the approximate per- centage of each being shown from a rough colony count: haemolytic Streptococcus longus, 1-0 per cent.; pneumo- coccus, 40 per cent.;Micrococcus catarrhtalis, 50 per cent."A second anal ulcer was observed on July 28th.By July 29th the patient was becoming increasingly weaker, the sclerotics appeared yellow, the sputum was foulsmelling and yellow in colour, and by 2 a.m. on July 30th she was semi-comatose; by 7 a.m.she was completely unconscious, and died at 1.30 p.m.The temperature rose to 106.60 F. before death.Examination of a blood film on July 29th showed that:" Many of the lymphocytes are larger than normal, with more cytoplasm, which stains more deeply than usual."Immediately after death the patient became a vivid yellow colour, with purple patches beginning in the face and continuing down the limbs and all over the body.